CEP-28122 mesylate ( —— )

产品货号. M16991 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

CEP-28122 mesylate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
产品描述

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
同义词

——
通路

Angiogenesis
靶点

ALK
受体

ALK
研究领域

——
适应症

——

CAS Number

——
分子量

635.17
分子式

C29H39ClN6O6S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 6.4 mg/mL; DMSO < 9.2 mg/mL
SMILES

——
化学全称

Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1)

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

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